Ohiopyle is a borough in Fayette County, Pennsylvania, United States. The population was 38 at the 2020 census. While Ohiopyle has a tiny year-round population, it is often filled with tourists on the weekend, who come for the outdoor recreation opportunities at the surrounding Ohiopyle State Park, as well as the Great Allegheny Passage bicycle trail which connects with the Chesapeake and Ohio Canal towpath trail to form a continuous 335-mile off-road trail from Pittsburgh, Pennsylvania to Washington, D.C. The borough of Ohiopyle is served by the Uniontown Area School District.